Evaluation of Irinotecan Liposome (II) Combined With 5-FU, LV, and Bevacizumab for mCRC

This study is testing a combination of chemotherapy drugs — including an irinotecan liposome injection, 5-FU, leucovorin, and bevacizumab — as a treatment for advanced colorectal cancer that has spread and cannot be removed by surgery. **You may be eligible if...** - You are between 18 and 75 years old - You have been diagnosed with stage IV colon or rectal cancer that cannot be surgically removed - Your cancer has progressed or you could not tolerate a prior chemotherapy regimen containing oxaliplatin - You are in generally good physical health (able to carry out light activity) - Your heart, liver, kidneys, and blood counts meet required levels **You may NOT be eligible if...** - You have had a different cancer in the past 5 years - Your cancer has a specific genetic marker (MSI-H or BRAF V600E mutation) suggesting other treatments may work better - Your cancer has spread to the brain - You have previously received irinotecan-based chemotherapy - You have serious heart, lung, or digestive problems - You are pregnant or breastfeeding Talk to your doctor to see if this trial is right for you.