TIPS Plus Half-dose Donafenib in AHCC with PVTT-associated Portal Hypertension

This study is testing whether combining a procedure called TIPS (a shunt placed in the liver to relieve pressure in the blood vessels) with a low dose of donafenib (a targeted cancer drug) can improve outcomes in patients with advanced liver cancer and serious complications from high pressure in the portal vein. **You may be eligible if...** - You are between 18 and 75 years old - You have pathologically confirmed liver cancer (hepatocellular carcinoma) with at least one measurable tumor - Your cancer is at an advanced stage with a tumor thrombus causing high portal vein pressure - You have not received any prior local or systemic cancer treatments - You have complications from portal hypertension such as gastrointestinal bleeding, ascites (fluid buildup), or pleural effusion - Your liver and organ function meet required levels **You may NOT be eligible if...** - You have received prior local or systemic cancer treatment - Your liver function is very poor (Child-Pugh score above 13) - You are pregnant or breastfeeding - Your blood counts or organ function fall below required thresholds Talk to your doctor to see if this trial is right for you.