RecruitingNot ApplicableNCT06649253

Childhood B-acute Lymphoblastic Leukaemia and Role of CD9 Gene Regulation in Relapse

REALL CD9 : Molecular Mechanisms Involved in Relapses of Childhood B-acute Lymphoblastic Leukaemia, Role of Non-coding RNA in CD9 Gene Regulation


Sponsor

Rennes University Hospital

Enrollment

50 participants

Start Date

Mar 22, 2025

Study Type

INTERVENTIONAL

Conditions

Summary

B-acute lymphoblastic leukaemia (B-ALL) is the most common cancer in children, with 20% of patients relapsing. CD9, a transmembrane protein, is linked to the migratory and adhesion capacities of leukaemia cells and could be associated with relapses. The aim of this project is to understand how CD9 regulation can be a marker of potential relapses, using bone and blood sampling of newly diagnosed patients at 3 crucial moments of therapy.


Eligibility

Min Age: 0 YearsMax Age: 17 Years

Plain Language Summary

Simplified for easier understanding

This study is investigating the role of a gene called CD9 in childhood B-cell acute lymphoblastic leukemia (B-ALL), a common childhood cancer of the blood. Researchers are collecting samples to understand how CD9 affects how the leukemia behaves and whether it could be targeted in future treatments. **You may be eligible if...** - Your child is under 18 years old - Your child has been diagnosed with B-ALL - The diagnosis was made at the participating center - You (as parent or guardian) have provided written informed consent **You may NOT be eligible if...** - The leukemia is only found in sites outside the bone marrow at the start of the study - The patient is of childbearing age without using effective contraception - The patient is subject to legal protection measures Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

OTHERSampling bone tissue and blood

Extra tube collection of bone and blood will be collected during routine care sampling interventions at the diagnosis, after the first phase of treatment and after relapse, if it occurs.


Locations(3)

CHU Angers

Angers, France

CHU Brest

Brest, France

CHU Rennes

Rennes, France

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NCT06649253


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