RecruitingNot ApplicableNCT06650033

Pelvis Adaptive Radiotherapy (ART)

Pelvis Adaptive Radiation Therapy


Sponsor

Royal North Shore Hospital

Enrollment

280 participants

Start Date

Oct 9, 2025

Study Type

INTERVENTIONAL

Conditions

Summary

Pelvis Adaptive radiotherapy (ART) is a two phase study looking at using adaptive radiotherapy to help reduce toxicity for cancer patients having radiotherapy in the pelvic region. Adaptive radiotherapy is a new technology that provides the ability to account for daily changes in anatomy. Adaptive radiotherapy also provides a foundation for which radiotherapy margins might be safely reduced. Phase 1 of this study is looking to see if a radiation therapist centred adaptive workflow can be implemented. If phase 1 of this study is safe and feasible, the study will proceed to phase 2. Phase 2 of the study looks at using adaptive technology to reduce radiation treatment margins. The primary aim of this study is to see whether margin reduced treatment using adaptive radiotherapy can reduce side effects for patients with cancer in the pelvic area.


Eligibility

Min Age: 18 Years

Inclusion Criteria11

  • Age \> 18
  • ECOG performance status 0-2
  • Patients receiving curative or adjuvant pelvic radiation including:
  • Prostate cancer where nodal treatment is required
  • Prostate cancer post prostatectomy
  • Bladder cancer
  • Rectal cancer
  • Anal cancer
  • Adjuvant radiotherapy for gynaecological cancers
  • Pelvic Lymph nodes only
  • Ability to understand and the willingness to sign an informed consent

Exclusion Criteria2

  • Hip prosthesis
  • Patient separation from approximate radiation centre to skin edge \> 24cm, measured on diagnostic scan

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Interventions

RADIATIONAdaptive radiotherapy +/- margin reduction

Radiotherapy using adaptive technology to recontour and re-plan daily as required. Reductions in the PTV margin will also be introduced in the second phase of this study.

RADIATIONImage guided radiotherapy

Standard radiation treatment used in the department of radiation oncology for cancer in pelvic area


Locations(1)

Northern Sydney Local Health District

St Leonards, New South Wales, Australia

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NCT06650033