Protective Ileostomy Versus Protective Colostomy in Anterior Rectal Resection
PROtective ileoStomy Versus ProtectivE Colostomy in Anterior Rectal resectIon - a Multicenter, Open-label, Randomized conTrolled studY (PROSPERITY)
Helsinki University Central Hospital
350 participants
Oct 6, 2025
INTERVENTIONAL
Conditions
Summary
Loop ileostomy and loop colostomy are both used as protective stomas after anterior resection. There is a lack of evidence on the superiority of loop ileostomy versus loop colostomy. This is a multicenter, open-label, superiority, individually randomized controlled trial including patients undergoing anterior rectal resection with primary anastomosis and a protective stoma. Patients scheduled for anterior rectal resection are randomized 1:1 to loop ileostomy or loop colostomy intraoperatively. Primary outcome is cumulative stoma-related adverse events within 60 days post-primary surgery (scored using Comprehensive Complication Index (CCI)).
Eligibility
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Interventions
Patient undergoing anterior rectal resection will receive loop ileostomy
Patient undergoing anterior rectal resection will receive loop colostomy
Locations(3)
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NCT06650085