RecruitingNot ApplicableNCT06651749
Hemodynamic Effects of a High Dose Versus Low Dose Propofol During Induction of Anesthesia.
Hemodynamic Effects of a High Dose Versus Low Dose Propofol During Induction of Anesthesia. a Randomized Comparative Trial.
Sponsor
Ain Shams University
Enrollment
70 participants
Start Date
Nov 1, 2024
Study Type
INTERVENTIONAL
Conditions
Summary
The investigators will test the hemodynamic effects of a high dose versus low dose Propofol during induction of anesthesia.
Eligibility
Min Age: 21 YearsMax Age: 40 Years
Inclusion Criteria3
- Age: from 21 years old till 40 years old.
- Patients with ASA classification I and II.
- Undergoing a scheduled elective surgery.
Exclusion Criteria11
- Declining to give written informed consent.
- ASA classification III-V.
- Patients with class III (morbid) obesity or more (BMI \>40 Kg/m2)
- Patients with severe intraoperative hypotension requiring large volume of intravascular fluid treatment.
- Severe or uncontrolled hypertension (NIBP\> 150/100) , congestive heart failure, moderate to severe valvular heart disease , uncontrolled arrhythmia , heart rate\>100bpm .
- Significant hepatic or renal disorder.
- Patients with uncontrolled diabetes mellitus type 1 or type 2(evidenced by autonomic dysfunction or organ complications, ischemic heart disease or cerebrovascular disease).
- Patients who were pregnant (positive pregnancy test) or menstruating.
- Anemia with hemoglobin level \<9.0 g/dL
- Hypersensitivity to soybean oil, egg lecithin, or glycerol.
- Medical substance abuse.
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Interventions
DRUGPropofol injection
hemodynamic changes of a high dose versus low dose propofol during induction of anesthesia.
Locations(1)
View Full Details on ClinicalTrials.gov
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NCT06651749