RecruitingNCT06652009

Radical Radiotherapy Versus Radical Surgery for UTUC

Efficacy of Radical Radiotherapy Compared with Surgical Treatment in Patients with Upper Tract Urothelial Carcinoma: a Prospective Cohort Study

Sponsor

Peking University First Hospital

Enrollment

60 participants

Start Date

Jan 1, 2022

Study Type

OBSERVATIONAL

Conditions

Renal Pelvis Cancer

Summary

This study is a prospective cohort study, and the proposed plan is to recruit 30 patients with radical radiotherapy for renal pelvic ureteral cancer, according to the actual clinical situation, enrolling the same period of time to choose the operation of the elderly, combined with the risk of anaesthesia or regional lymph node metastasis of the patients, initially tentatively set at 60. The patients were divided into the surgery group and radiotherapy group according to the actual choice of treatment. In the control group, standard nephroureterectomy was used, and in the experimental group, stereotactic body radiation therapy (SBRT) or moderately segmented radical radiotherapy was used.

Eligibility

Min Age: 18 YearsMax Age: 80 Years

Plain Language Summary

Simplified for easier understanding

This study is comparing radiation therapy versus surgery for patients with cancer of the renal pelvis or ureter (the tubes that carry urine from the kidney to the bladder) — a type of cancer called upper tract urothelial carcinoma (UTUC). **You may be eligible if...** - You have been diagnosed with cancer of the renal pelvis or ureter, confirmed by imaging, biopsy, urine testing, or specialized genetic tests - Your cancer is considered suitable for either surgery or radiation - You are willing to be randomly assigned to one of the two treatment approaches **You may NOT be eligible if...** - Your cancer has spread to distant organs (stage IV) - You have already received treatment for this cancer - You have conditions that make you unsuitable for surgery or radiation - You have another active cancer Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

OTHERRadical nephroureterectomy

Radical nephroureterectomy

RADIATIONRadical radiotherapy

Radical radiotherapy with stereotactic body radiation therapy (SBRT) or moderately segmented radiotherapy

Locations(2)

Departmeng of Urology, Peking University First Hospital

Beijing, China

Department of Radiotherapy Oncology, Peking University First Hospital

Beijing, China

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NCT06652009