Study and Role of Inflammasome in Platelet Activation During Bacterial And/or Viral Sepsis
Centre Hospitalier Universitaire de la Guadeloupe
171 participants
Nov 30, 2022
OBSERVATIONAL
Conditions
Summary
: Sepsis, now defined as life-threatening organ dysfunction due to a dysregulated host response to infection, is an important global health problem representing about a fifth of all global deaths. It can be associated, in some cases, with multiple organ failure and cytokine storm. The main objective of this study is to estimate and to compare the activation rate of the Nucleotide-binding domain Leucine Rich repeat containing Protein 3 (NLRP3) inflammasome in platelets between five groups of patients suffering from bacterial and/or viral sepsis, with different severity levels according to Sequential Organ Failure Assessment (SOFA) score to precise the platelets' implication in this cytokine storm.
Eligibility
Inclusion Criteria3
- For all groups: patients older than 18 years at inclusion and acceptation of participation by the patient, his relative or his legal representative (depending on the situation)
- For groups 1, 2, 3 and 5: Patient with a confirmed sepsis (microbiological confirmation)
- For group 4 : Patient non infected
Exclusion Criteria3
- Refusal of participation by the patient, his relative or his legal representative (depending on the situation)
- Patients subject to a safeguard measure of justice
- Patients younger than 18 years at inclusion
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Locations(1)
View Full Details on ClinicalTrials.gov
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NCT06657781