Clinical Trial Evaluating Secondary HPV Vaccination After Treatment of High-grade Cervical Lesions

This study looks at whether getting the HPV vaccine (Gardasil 9) after treatment for a high-grade precancerous cervical lesion can reduce the chance of the abnormal cells coming back, especially in women over 45 who still test positive for HPV after their procedure. **You may be eligible if...** - You are a woman over 45 years old - You previously had treatment (called a conization) for a high-grade abnormal cervical finding - You tested positive for HPV at your 6-month follow-up appointment - You are willing to receive the HPV vaccine (Gardasil 9) - If you have HIV, you are on antiretroviral therapy **You may NOT be eligible if...** - You have an allergy or contraindication to the HPV vaccine - You are unwilling to be vaccinated (you may still be eligible for a data-only arm of the study) Talk to your doctor to see if this trial is right for you.