RecruitingNot ApplicableNCT06659146

Thermotherapy in Addition to SOC Palliative Radiotherapy

Prospective Study to Assess the Real-world Implementation of Thermotherapy Using wIRA (Water-filtered Infrared A Superficial Hyperthermia) in Addition to Standard of Care (SOC) Palliative Radiotherapy (RT)


Sponsor

King's College London

Enrollment

60 participants

Start Date

Oct 14, 2024

Study Type

INTERVENTIONAL

Conditions

Summary

This study aims to investigate the efficacy and safety profile of superficial hyperthermia (wIRA) in addition to standard of care (SOC) palliative radiotherapy in patients with inoperable/incurable locally advanced or recurrent/metastatic HNSCC or cutaneous SCC superficial tumours not suitable for radical treatment. The investigators will assess the best objective response rate (ORR) of patients with Inoperable/incurable or recurrent/metastatic HNSCC or cSCC with superficial lesion(s) treated with the combination of superficial hyperthermia (wIRA) and palliative radiotherapy.


Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This study tests whether adding heat therapy (thermotherapy using a device called Hydrosun) alongside standard palliative radiation therapy improves pain relief or tumor response in people with incurable cancer that has spread near the skin or to lymph nodes. **You may be eligible if...** - You are 18 or older with confirmed cancer that cannot be cured or operated on - You have a tumor close to the skin surface or a swollen lymph node that is suitable for heat treatment - You are already scheduled for palliative radiation therapy - You are generally well enough to carry out daily activities (ECOG 0–1) **You may NOT be eligible if...** - You do not have a suitable superficial tumor or lymph node for heat treatment - Your radiation plan doesn't match the specific doses used in this study - You have a psychiatric disorder or substance use problem that would affect participation Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DEVICESuperficial hyperthermia

Superficial hypothermia will be delivered using a CE-marked water-filtered infrared A (wIRA) machine (hydrosun® TWH1500)


Locations(2)

Guy's and St. Thomas NHS Foundation Trust

London, United Kingdom

Guy's Cancer Centre

London, United Kingdom

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NCT06659146


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