RecruitingNot ApplicableNCT06660706

The Effects of Exercise Intervention on Skeletal Muscle and Other Organs in Aged Population and the Discovery of Associated Circulating Biomarkers

Sponsor

National Yang Ming Chiao Tung University

Enrollment

100 participants

Start Date

Apr 1, 2024

Study Type

INTERVENTIONAL

Conditions

Age-related Functional Decline

Summary

This project aims to investigate the intricate interplay between skeletal muscle and adipose tissue during the aging process by integrating human studies. Utilizing interventional research and randomized trials combined with examining blood samples from elderly individuals engaged in exercise, we aim to investigate the effects of exercise on muscle health and explore the underlying mechanisms of muscle aging and related biomarkers. Interdisciplinary research allowed us to investigate the systemic impact of exercise on muscles. This approach allowed us to gain a better understanding of the interconnectedness of skeletal muscle and adipose tissue in the aging process and devise efficient strategies to reverse age-related changes. These findings hold promise for promoting a future society where long and healthy life is achievable for all.

Eligibility

Min Age: 65 Years

Inclusion Criteria2

aged ≥ 65 years
slow gait speed (\<1 m/s in 6-meter walk test) or weakness (dominant handgrip strength \<28 kg in men, \<18 kg in women)

Exclusion Criteria4

established diagnosis of dementia, Parkinsonism or other mobility-limiting, disable conditions
active, acute diseases receiving treatment, such as cancer, heart failure, COPD and so on
estimated life expectancy \<12 months
current nursing home residents

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Interventions

BEHAVIORALMulti-domain intervention

Each session comprises of 45 minutes physical fitness activities targeting on muscle strength, balance, and flexibility; 1-hour cognitive training primarily on reasoning and memory exercises; and 15-minute for nutritional advices based on national diet guidelines for older adults

Locations(1)

Center for Healthy Longevity and Aging Sciences, National Yang Ming Chiao Tung University

Taipei, Taiwan

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NCT06660706

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