RecruitingNCT06661174
A Cohort Study on the Efficacy of Bariatric Surgery for Rapidly Progressing Diabetic Nephropathy
Sponsor
China-Japan Friendship Hospital
Enrollment
100 participants
Start Date
Oct 1, 2023
Study Type
OBSERVATIONAL
Conditions
Summary
Establish a cohort of diabetic kidney disease(DKD) patients with intensive weight loss treatment to evaluate the impact of intensive weight loss treatment on the renal prognosis of DKD and construct a prediction model for the improvement of renal outcomes after weight loss.
Eligibility
Min Age: 18 YearsMax Age: 65 Years
Inclusion Criteria3
- Age 18 to 65 years old;
- BMI>25Kg/m2 or abdominal obesity (i.e. waist circumference>90cm for men and>85cm for women);
- eGFR<30ml/min/1.73m2 or urinary microalbumin≥300mg/g, eGFR<60ml/min/1.73m2.
Exclusion Criteria2
- Patients who are taking glucocorticoids;
- Combined with tumors; ③Combined with autoimmune diseases; ④Serum albumin<25g/L.
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Interventions
PROCEDUREBariatric surgery
Laparoscopic sleeve gastrectomy or laparoscopic gastric bypass based on β-cell function
OTHERNon-surgical therapy
Diet management，exercise，metformin，GLP-1 receptor agonists and other drugs which can lose weight.
Locations(1)
View Full Details on ClinicalTrials.gov
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NCT06661174
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