RecruitingNCT06661278

Evaluation of Exercise Testing and Physical Activity in Children and Adolescents Living With Inherited Arrhythmias

Evaluation of Free-living Physical Activity and the Assessment Tools Used to Support Pharmacological Therapy Titration and Exercise Prescription in Children and Adolescents Diagnosed With Inherited Arrhythmias

Sponsor

Royal Brompton & Harefield NHS Foundation Trust

Enrollment

110 participants

Start Date

Mar 18, 2025

Study Type

OBSERVATIONAL

Conditions

Long QT Syndrome Catecholaminergic Polymorphic Ventricular Tachycardia Type 1 Catecholaminergic Polymorphic Ventricular Tachycardia Type 2

Summary

The goal of this observational study is to evaluate exercise testing and daily physical activity in children and adolescents who are diagnosed with an inherited arrhythmia. The main question it aims to answer is: Does maximum heart rate during controlled exercise tolerance testing accurately reflect maximum heart rate and peak exercise levels during free living daily physical activity in children and adolescents diagnosed with an inherited arrhythmia? Participants will: * Complete routine exercise tolerance testing * Record daily physical activity and exercise over two weeks, while wearing an activity and heart rate monitor and digit diary. * Complete a physical activity questionnaire at the end of two weeks.

Eligibility

Min Age: 6 YearsMax Age: 16 Years

Inclusion Criteria12

Affected cohort
Male and female children
Aged 6-16 years
Diagnosed with long QT syndrome or catecholaminergic polymorphic ventricular tachycardia
Treated with beta-blocker and/or sodium channel blockade
Able to complete a treadmill ETT
Healthy cohort
Male and female children
Aged 6-16 years
Siblings of affected children (gene negative)
Undergoing IAS screening
Able to complete a treadmill ETT

Exclusion Criteria5

Children aged less than 6 years
Adults, 17 years of age and above
Unable to run on an exercise treadmill due to physical limitations.
Individuals unable to speak or understand English, due to no translation service available.
Pregnancy

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Interventions

DIAGNOSTIC_TESTExercise tolerance test

Clinical routine exercise tolerance test using an exercise treadmill, according to the arrhythmia protocol (15 minute protocol utilising increasing speed and incline with a 6 minute recovery)

OTHERPhysical activity & heart rate monitoring

Physical activity monitoring over two weeks using Actiheart and Pro-Diary monitors to record heart rate, heart rhythm, activities engaged in and estimated intensity of activities.