A Research Protocol for Evaluating the Efficacy of Perfused Chemotherapeutic Agents for Bladder Cancer Based on Organoid Technology

This study is testing whether growing miniature versions of a patient's bladder tumor in the lab (called organoids) can help predict which chemotherapy drugs will work best when delivered directly into the bladder — a procedure called bladder perfusion therapy — for people with early-stage, non-muscle-invasive bladder cancer. **You may be eligible if...** - You are between 18 and 80 years old - You have been diagnosed with intermediate or high-risk bladder cancer that has not spread into the muscle wall - You have not received prior bladder chemotherapy instillation treatment (except for a one-time dose right after surgery) - You are able to follow the study procedures and attend follow-up visits **You may NOT be eligible if...** - You had a bladder tear, major bleeding, or a serious bladder infection after your most recent surgery - You have a weakened immune system (e.g., HIV/AIDS, on immunosuppressive medications) - You are allergic to the study drugs - You have been taking hormonal drugs long-term or have a history of drug dependence - You are pregnant, breastfeeding, or planning a pregnancy soon - Your blood counts or organ function tests (liver, kidneys) are below acceptable levels Talk to your doctor to see if this trial is right for you.