GYNecologic Cancer-Related COGnitive Impairment
A Pilot and Mixed-Methods Study of GYNecologic Cancer-Related COGnitive Impairment
Northwestern University
60 participants
Feb 7, 2025
INTERVENTIONAL
Conditions
Summary
The goal of this study is to test a home-based and patient-tailored cognitive training intervention among gynecologic cancer patients who have completed chemotherapy and who have experienced cancer-related cognitive impairment.
Eligibility
Inclusion Criteria5
- Female; ≥18 years of age
- Presents to clinic with a confirmed diagnosis of a gynecologic cancer (e.g., ovarian, endometrial, cervical, or vulvar cancer) who have completed adjuvant chemotherapy with at least stable disease at time of screening.
- Screen positive for subjective cognitive impairment by answering affirmatively to at least one of three screener questions
- Fluent in spoken and written English
- Have access to the internet to complete assessments
Exclusion Criteria7
- Patients who have not received chemotherapy
- Patients with pre-existing neuropsychiatric disorders that would impact cognitive function, such as dementia, Alzheimer's disease, and schizophrenia.
- Patients with non-gynecologic causes of incurable metastatic cancers.
- Patients undergoing active interventions in other cognitive trials or patients currently using cognitive training programs such as Brain HQ, Luminosity, Elevate, Peak, Fit Brains, or CogniFit.
- Patients with self-report of learning disability or an unwillingness to participate in technology-based cognitive training programs.
- Pregnant women or prisoners
- Patients with impaired-decision making capacity
Interventions
Participants in the GYNCOG arm will be asked to participate in a home-based cognitive training program utilizing BrainHQ. Participants will be instructed to use the Brain HQ app for approximately 2.5 hours per week. Patients will be provided with a calendar to help keep track of daily BrainHQ use, including the number of exercises completed and the amount of time spent on the app per day. Patients will be asked to undergo the exercises that target the speed and accuracy of information processing. Examples of the exercises include: Double Decision: This exercise tests your ability to quickly identify and choose between two options. Eye for Detail: It challenges participants to spot small differences between two similar images. Participants will be asked to train approximately 30 minutes per BrainHQ session, 5 times per week (i.e., 2.5 hours per week) for 10 weeks, for a total of approximately 25 hours.
Locations(1)
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NCT06662435