RecruitingNot ApplicableNCT06669182

Advantage of Cerebellar Transcranial Magnetic Stimulation in Alzheimer's Diseases （ACT-AD）

Effects of Cerebellar Transcranial Magnetic Stimulation on Patients With Alzheimer's Disease：A Multicenter Randomized Controlled Trial

Sponsor

Xijing Hospital

Enrollment

100 participants

Start Date

Jan 7, 2025

Study Type

INTERVENTIONAL

Conditions

Alzheimer Disease Transcranial Magnetic Stimulation Cerebellum

Summary

Alzheimer's Disease (AD) is the primary cause of dementia, with its prominent feature being cognitive decline. The cerebellum plays a crucial role in cognitive processing, making it a potential target for therapeutic intervention. This study will be conducted to evaluate the efficacy and safety of cerebellar Intermittent theta-burst stimulation (CRB-iTBS) in participants with mild Alzheimer's disease on the change from baseline in the Clinical Dementia Rating-Sum of Boxes (CDR-SB) at 3 months of treatment in the Core Study. This project aims to provide a valid treatment to improve the cognitive function and quality of life for those with Alzheimer's disease.

Eligibility

Min Age: 50 YearsMax Age: 85 Years

Plain Language Summary

Simplified for easier understanding

This study (ACT-AD) tests whether applying transcranial magnetic stimulation (TMS) — a non-invasive brain stimulation technique using magnetic pulses — to the cerebellum (the back of the brain) can improve thinking, memory, and daily function in people with mild to moderate Alzheimer's disease. **You may be eligible if...** - You are 50–85 years old - You have a diagnosis of Alzheimer's disease with confirmed biomarker evidence (PET scan or spinal fluid) - Your cognitive score (MMSE 18–26, CDR 0.5–1) falls in the mild to moderate range - You are already on stable Alzheimer's medication for at least 12 weeks - You have at least one adult caregiver **You may NOT be eligible if...** - You have another brain condition (e.g., Parkinson's, stroke, brain tumor) - You have a history of seizures (other than childhood febrile seizures) - You have severe depression, schizophrenia, or bipolar disorder - You have a pacemaker, deep brain stimulator, or metal implants - You are pregnant or breastfeeding Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DEVICEIntermittent Theta-Burst Transcranial Magnetic Stimulation

50Hz, stimulation intensity of 100% RMT, duration of 40s as a group of stimulation, 600 stimulation pulses, repeated stimulation of bilateral cerebellar dentate nuclei, with a 5-minute interval between each group, 1200 stimulation pulses per site, 5 times a week, treatment for 4 weeks, then treat once a week for 8 weeks.