RecruitingNCT06675110

QuEST - Quick and Easy Scrub Typhus Diagnostic Tools

Diagnostic Tools for the Direct Detection of Orientia Tsutsugamushi

Sponsor

University of Oxford

Enrollment

100 participants

Start Date

Jul 17, 2024

Study Type

OBSERVATIONAL

Conditions

Evaluate the performance of insulated isothermal polymerase chain reaction (iiPCR) in the diagnosis of scrub typhus in Chiang Rai Province

Min Age: 7 Years

Acute (duration ≤14 days) fever (37.5°C or higher or a history of fever in the previous 24h) AND
Eschar OR
≥ 2 of the following:
Living in rural parts of Chiangrai Province or other ST risk areas
History of outdoor risk activities in the 2 weeks before symptom onset
Presenting during the rainy season or early cold season
Two or more of: headache; myalgia, cough, abdominal symptoms (abdominal pain/ nausea-vomiting); myalgia; lymphadenopathy AND
≥ 7 years old AND
Weight>15Kg AND
The patient and/or where relevant their parent/guardian/caretaker/legally acceptable representative willing and able to give informed consent /assent for participation in the study AND Positivity to any of the screening tests (Immunochromatographic RDT or iiPCR)

\- Other clear focus of infection (e.g. lobar pneumonia by chest x-ray, abscess) OR Other clear cause of fever (e.g. positive Dengue IgM or NS1 antigen, positive blood cultures, untreated HIV)

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Mae Chan District Hospital

Mae Chan, Changwat Chiang Rai, Thailand

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NCT06675110