RecruitingPhase 2NCT06675357

Using FAPI PET/MRI to Evaluate Prostate Cancer

Novel FAP-targeted Approach to Imaging Patients With or High-risk for Metastatic Prostate Cancer


Sponsor

University of Wisconsin, Madison

Enrollment

30 participants

Start Date

Feb 27, 2026

Study Type

INTERVENTIONAL

Conditions

Summary

The goal of this clinical trial is to gain more information about how FAPI (fibroblast activation protein inhibitor) binds to certain type of cells in the tumor tissue. The main question it aims to answer is how this information can be used to better diagnose and track prostate cancer. Participants will undergo two PET/MRI scans during two research visits, each of which may last up to 2.5 hours.


Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This study is testing a new type of imaging scan called FAPI PET/MRI to see how well it detects and characterizes prostate cancer compared to the current standard imaging scan (PSMA PET). FAPI targets a protein found in the tissue surrounding tumors, which may help identify cancer that the standard scan misses. **You may be eligible if...** - You are 18 or older with a known diagnosis of prostate cancer - You are already scheduled for or recently had (within 4 weeks) a standard PSMA PET scan as part of your care - You are willing and able to undergo a PET/MRI scan **You may NOT be eligible if...** - You have a medical reason you cannot have a PET/MRI (such as certain metal implants or severe claustrophobia that cannot be managed with mild oral medication) - Doing the additional research scan would delay your treatment - You require intravenous sedation for imaging Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

RADIATIONFAPI

5 +/- 2 mCi of Ga-FAPI-46

PROCEDUREPositron Emission Tomography (PET)

Undergo PET scan

PROCEDUREMagnetic Resonance Imaging

Undergo MRI scan


Locations(1)

University of Wisconsin

Madison, Wisconsin, United States

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NCT06675357


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