RecruitingNot ApplicableNCT06675942

Evaluating the Short-term Efficacy of Two Oscillation Techniques in Hypersecretive Mechanically Ventilated Patients

Evaluating the Short-term Efficacy of Two Oscillation Techniques in Hypersecretive Mechanically Ventilated Patients: a Randomized Crossover Trial


Sponsor

Capital Medical University

Enrollment

24 participants

Start Date

Nov 10, 2024

Study Type

INTERVENTIONAL

Conditions

Summary

Although mechanical ventilation (MV) is life-saving, it is associated with several complications. The establishment of an artificial airway impairs the cough reflex and mucociliary function, leading to the accumulation of secretions in the tracheobronchial tree. This increases the risk of pneumonia and lung atelectasis. Usual care for mechanically ventilated patients includes airway suctioning via the tracheostomy tube, which clears only a limited portion of the airway and is ineffective at removing peripheral airway secretions. To address this, airway clearance guidelines recommend various airway clearance techniques (ACTs) for mechanically ventilated patients to enhance mucus removal. However, the lack of standardized, effective evaluation criteria makes selecting the optimal ACT a challenge.


Eligibility

Min Age: 18 Years

Inclusion Criteria2

  • Eligible participants were patients aged ≥18 years with airway hypersecretion, admitted to the ICU,
  • Requiring more than 48 hours of MV.

Exclusion Criteria9

  • Malignant arrhythmia
  • Acute myocardial ischemia
  • Pneumothorax, pulmonary bulla, barotrauma, or other lung diseases,
  • Hemorrhagic disease or coagulation abnormalities with bleeding tendencies
  • Skin trauma on the chest
  • Pulmonary embolism
  • Presence of a permanent or temporary pacemaker
  • Untreated spinal and rib fractures
  • Any condition deemed inappropriate for study inclusion by the researchers.

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Interventions

DEVICEOscillation and Lung Expansion

The OLE device (MetaNeb system) is a newer, noninvasive physiotherapy tool that combines mechanical and pharmacological interventions (aerosols) to help mobilize endobronchial secretions.

DEVICEHigh-frequency chest wall oscillation

High-frequency chest wall oscillation (HFCWO) is an airway clearance technique that uses external forces applied to the chest via an inflatable vest connected to a device that generates vibrations at varying frequencies and pressures.


Locations(1)

Beijing Rehabilitation Hospital

Beijing, China

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NCT06675942