A Novel Strategy of ECMO Management Using Nafamostat for Regional Combined With Low Intensity Systematic Anticoagulation
A Novel Strategy Combined Regional Anticoagulation in Membrane Oxygenator and Low-intensity of Systemic Anticoagulation Applied in Management of Extracorporeal Membrane Oxygenation
Beijing Chao Yang Hospital
60 participants
Nov 1, 2024
INTERVENTIONAL
Conditions
Summary
ECMO is widely used in patients with refractory respiratory and/or circulatory failure.The data shows that the incidence of bleeding and thrombotic events is still above 40%,and it is closely related to the increase in mortality rate.Therefore, optimizing ECMO anticoagulation management to reduce bleeding and thrombotic events is a key scientific issue that urgently needs to be addressed.
Eligibility
Inclusion Criteria2
- age older than 18 years old
- received ECMO because of severe respiratory failure
Exclusion Criteria7
- anticoagulant contraindications
- cerebral infarction or suspected patients
- severe hypertension
- women in gestational and lactational period
- hemophilia
- allergic to heparin or Nafamostat
- unwilling or unable to complete the study
Interested in this trial?
Get notified about updates and connect with the research team.
Interventions
Nafamostat combined with unfractionated heparin for anticoagulation
unfractionated heparin for anticoagulation
Locations(1)
View Full Details on ClinicalTrials.gov
For the most up-to-date information, visit the official listing.
NCT06676085