A Randomized Crossover Trial of Bright Light Therapy in Irritable Bowel Syndrome

Exclusion Criteria9

• Subject that are pregnant or plan to become pregnant.
• Night shift workers or people who have crossed more than 2 time zones in the previous 4 weeks.
• Regular use of medications that affect intestinal permeability, and/or endogenous melatonin including metoclopramide, NSAIDs, beta blockers, antibiotics, psychotropic medications, hypnotics and exogenous melatonin products during 4 weeks prior to the study.
• Any major organ disease - known renal impairment, diabetes, liver disease, or significant cardiac failure (NY classification stage III/IV), inflammatory bowel disease or celiac disease per chart review and/or medical history.
• Diagnosis of narrow angle glaucoma or retinal disorders or demonstrated symptoms indicative of these diagnosis during the eligibility screening.
• Moderate to severe depression (score ≥ 21 or any endorsement of suicidal intent on the Beck Depression Inventory) 19
• Sleep apnea (score high risk in 2 or more categories of the Berlin Questionnaire) 20
• Restless leg syndrome (score ≥ 15 on the IRLS Study Group Rating Scale) 21
• Inability or unwillingness of subject to sign an informed consent