RecruitingNot ApplicableNCT06676956

The SEQUENCE Trial

The SEQUENCE Trial: Should Endobronchial Ultrasound QUeue bEfore or eNsuing to robotiC-assisted Bronchoscopy for pEripheral Pulmonary Nodule Biopsy?

Sponsor

Northwestern University

Enrollment

320 participants

Start Date

Nov 10, 2024

Study Type

INTERVENTIONAL

Conditions

Pulmonary Nodules

Summary

This study will randomize participants undergoing a bronchoscopic biopsy of a peripheral pulmonary nodule for their standard of care to receive robotic-assisted bronchoscopy (RaB) and then staging linear endobronchial ultrasounnd (EBUS) OR staging linear EBUS first, followed by RaB. The goal of this study is to set the standard for optimizing the sequence of bronchoscopic procedures in patients at risk for early-stage malignancy.

Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This trial evaluates the best sequence for two procedures performed together during a single bronchoscopy: robotic-assisted bronchoscopy (a flexible camera-guided tool to reach lung nodules) and EBUS (a technique to sample lymph nodes). It tests whether doing lymph node sampling first or second affects how well the lung nodule can be diagnosed. **You may be eligible if...** - You have a small spot or nodule in the outer part of your lung that needs to be biopsied - You are scheduled for robotic-assisted bronchoscopy to evaluate the nodule **You may NOT be eligible if...** - Your lymph nodes are enlarged or show high activity on PET scan before the procedure (suggesting they need separate evaluation) Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DIAGNOSTIC_TESTLinear EBUS first

Patients randomized to this arm will undergo a mediastinal lymph node evaluation with EBUS first, followed by biopsy followed by robotic-assisted bronchoscopy.

DIAGNOSTIC_TESTRobotic-assisted bronchoscopy first

Patients randomized to this arm will undergo a robotic-assisted bronchoscopy first, followed by a mediastinal lymph node evaluation with EBUS second

Locations(5)

University of California, Davis

Sacramento, California, United States

Northwestern University

Chicago, Illinois, United States

Johns Hopkins University

Baltimore, Maryland, United States

University of Michigan

Ann Arbor, Michigan, United States

University of North Carolina, Chapel Hill

Chapel Hill, North Carolina, United States

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NCT06676956

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