RecruitingNot ApplicableNCT06678295

Individual Factors of CBT Underlying Success

Contributions of Self-Focused Attention to Early Warning Indicators of Cognitive Behavioral Therapy Non-Response

Sponsor

University of Washington

Enrollment

160 participants

Start Date

Oct 15, 2024

Study Type

INTERVENTIONAL

Conditions

Social Anxiety Disorder Body Dysmorphic Disorder

Summary

The purpose of this study is to understand why some individuals respond fully to cognitive behavioral therapy and others do not, based on multiple sources of data such as neural, neurocognitive, clinical, and self-report data.

Eligibility

Min Age: 18 YearsMax Age: 45 Years

Inclusion Criteria9

Clinical sample (N=110):
Men and women, age 18-45
Treatment-seeking individuals who meet criteria for a primary DSM-5 diagnosis of primary social anxiety disorder (SAD) or body dysmorphic disorder (BDD) based on the SCID-5-RV
Fluent in English and willing to provide informed consent.
Control sample (N=50):
Men and women, age 18-45
No current or lifetime history of psychiatric disorders, as assessed using the SCID-5-RV
Meet criteria for low levels of anxiety (GAD-7 score of \<8) and depression (PHQ-9 score \<10)
Fluent in English and willing to provide informed consent

Exclusion Criteria4

All groups:
Score \< 80 based on WRAT5 Word Reading Subtest
fMRI contraindications (e.g., electronic medical devices such as pacemakers, implanted defibrillators, etc.; metal implants not approved for MRI; pregnancy; claustrophobia)
\. Active suicidal or homicidal ideation, or any features requiring a higher level of care 3. Lifetime history of manic or hypomanic episode, psychotic symptoms, traumatic brain injury, neurological disorder, pervasive developmental disorder, or attention deficit-hyperactivity disorder; active alcohol or substance use disorder in the past 6 months 4. Current use of psychotropic medications, except antidepressants taken at a stable dose for 3 months prior to study baseline 5. Previous CBT non-responder or current CBT