A Study to Assess the Safety and Clinical Activity of Azer-cel in Participants With B-cell Mediated Autoimmune Disorders

This study tests a new CAR-T cell therapy called azer-cel in people with progressive forms of multiple sclerosis (MS). CAR-T therapy is a treatment where your immune cells are re-engineered to target and eliminate the abnormal immune cells causing MS. **You may be eligible if...** - You have been diagnosed with Primary Progressive or Secondary Progressive MS - You have stopped your current MS disease-modifying medication before enrolling and met the required washout period **You may NOT be eligible if...** - You have had a cancer that has not been in remission for at least 2 years - You have active or chronic hepatitis B, or you are HIV positive - You have previously had a bone marrow, stem cell, or organ transplant - You have previously received CAR-T cell therapy or any gene therapy Talk to your doctor to see if this trial is right for you.