RecruitingNot ApplicableNCT06681948

The Ketogenic Diet in the Treatment of Alzheimer's Disease

A Randomized, Double-Blind, Placebo Parallel-Controlled, Multicenter Clinical Study for Evaluating the Efficacy, Safety and Tolerability of JT821 in the Treatment of Mild and Moderate Alzheimer's Disease

Sponsor

Capital Medical University

Enrollment

300 participants

Start Date

Mar 20, 2024

Study Type

INTERVENTIONAL

Conditions

Alzheimer Disease

Summary

This research is a randomized, double-blind, placebo-parallel controlled, and multi-center clinical study in China, aiming to evaluate the tolerability, efficacy, and safety of JT821 (Ketogenic Diet) in the treatment of mild to moderate Alzheimer's disease. The ketogenic diet (KD) is a low-carbohydrate, adequate protein and high-fat diet. KD was shown to be effective in treating different neurodegenerative diseases.

Eligibility

Min Age: 50 YearsMax Age: 85 Years

Plain Language Summary

Simplified for easier understanding

This study tests whether a ketogenic diet (a very low-carbohydrate, high-fat diet) can slow the progression of Alzheimer's disease in people with mild to moderate symptoms, by providing the brain with an alternative energy source. **You may be eligible if...** - You are between 50 and 85 years old - You have completed at least primary school education and can participate in cognitive tests - You have been diagnosed with probable Alzheimer's disease based on recognized criteria - You have had memory problems for at least 12 months that have been slowly getting worse - Your cognitive test scores fall in the mild to moderate range (MMSE between 11 and 25) **You may NOT be eligible if...** - You have a different type of dementia (e.g., vascular dementia, Lewy body dementia) - You have uncontrolled diabetes or significant heart, kidney, or liver problems - You have severe Alzheimer's disease Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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