RecruitingNot ApplicableNCT06685913

The Effect of Ketone Esters on Forearm Glucose Metabolism

Sponsor

University of Exeter

Enrollment

14 participants

Start Date

Nov 11, 2024

Study Type

INTERVENTIONAL

Conditions

Healthy

Summary

Ketones are naturally produced by our body and can affect our blood sugar levels. Ketones could be important tool for treating disease or recovering from exercise. The purpose of this research is to determine if a ketone drink can increase sugar uptake in our muscles. This research will provide new knowledge about the regulation of blood sugar.

Eligibility

Min Age: 18 YearsMax Age: 40 Years

Inclusion Criteria1

Age 18-40

Exclusion Criteria8

Any diagnosed metabolic health condition
Pregnant
Smoker
Diagnosed Cardiovascular disease
Use of medications deemed by research team to affect study outcomes
Recent history of musculoskeletal injury
Aged >40 or <18
Allergy to ingredients in the supplement, including ketones, lactose or milk protein

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Interventions

DIETARY_SUPPLEMENTKetone supplement

100 mL flavoured drink containing 0.3 g/kg ketone monoester ((R)-3-hydroxybutyl (R)-3-hydroxybutyrate; ΔG®, University of Oxford; https://www.deltagketones.com) consumed 30 min prior to a mixed meal tolerance test

DIETARY_SUPPLEMENTPlacebo supplement

Placebo with bitter agent to flavour match, consumed 30 min prior to a mixed meal tolerance test