RecruitingPhase 2NCT06686030

Combination Therapy of AK112 With Chemotherapy and/or Olaparib in Platinum-sensitive Ovarian Cancer

An Exploratory, Multi-cohort Phase II Study of Combination Therapy of AK112 With Chemotherapy and/or Olaparib in Platinum-sensitive Ovarian Cancer


Sponsor

Akeso

Enrollment

150 participants

Start Date

Feb 17, 2025

Study Type

INTERVENTIONAL

Conditions

Summary

An Exploratory, Multi-cohort Phase II Study of combination therapy of AK112 with chemotherapy and/or olaparib in platinum-sensitive ovarian cancer(PSOC)


Eligibility

Sex: FEMALEMin Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This study tests a combination of an immunotherapy drug (AK112, which targets both PD-1 and VEGF), chemotherapy, and/or a PARP inhibitor (olaparib) in women with platinum-sensitive ovarian cancer — meaning cancer that responded to platinum-based chemotherapy but has since come back more than 6 months after the last treatment. **You may be eligible if...** - You are a woman aged 18 or older - You have been diagnosed with epithelial ovarian, fallopian tube, or primary peritoneal cancer - Your cancer is platinum-sensitive (came back more than 6 months after last platinum-based treatment) - You have measurable disease on a scan - You are physically functional (ECOG 0–1) **You may NOT be eligible if...** - Your cancer is of a mucinous type or other rare subtype - You have brain metastases - You have an active autoimmune disease - You have had previous immunotherapy treatment - You are pregnant or breastfeeding - You have active hepatitis B or C, or HIV - You have a history of interstitial lung disease Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DRUGAK112 low dose

10mg/kg, Q3W, ivgtt

DRUGChemotherapy

ivgtt

DRUGOlaparib

bid, oral

DRUGAK112 high dose

20mg/kg, Q3W, ivgtt


Locations(1)

Union Hospital Tongji Medical College Huazhong University of Science And Technology

Wuhan, China

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NCT06686030


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