Treating Parkinson's Disease Through Transplantation of Autologous Stem Cell-Derived Dopaminergic Neurons

This study tests whether transplanting a patient's own stem cell-derived dopamine neurons (brain cells grown from their own stem cells) into the brain can restore function in people with moderately advanced Parkinson's disease. **You may be eligible if...** - You have been diagnosed with Parkinson's disease for at least 5 years - You are between 45 and 80 years old - Your motor symptoms significantly improve with levodopa medication (at least 30% improvement) - You have at least 3 hours of "off" time per day (when your medication is not working well) - You are proficient in English and understand the consent process - You have a modified Hoehn and Yahr stage of 3–4 when off medication **You may NOT be eligible if...** - You have dementia or a low cognitive test score (MoCA below 26) - You have atypical Parkinsonism (e.g., multiple system atrophy, PSP) - You have a known genetic form of Parkinson's disease or a first-degree relative with the condition - You have a history of stroke, brain hemorrhage, or prior brain surgery (including DBS) - You have psychosis or serious psychiatric illness - You have uncontrolled blood pressure or poorly controlled blood sugar - You are pregnant or nursing Talk to your doctor to see if this trial is right for you.