RecruitingNot ApplicableNCT06689111

Correlation of Typical LBBB Mechanical Activation Pattern by 2D Strain Echocardiography With Acute GWE Improvement in Patients Receiving LBBp or Conventional BiVp for Cardiac Resynchronization Therapy (Echo LBBp)

Investigation of Whether the Presence of the Typical LBBB- Mechanical Stimulation Pattern - Documented Through 2DSE (Two-dimensional Strain Echocardiography) - is Associated With Increased Rates of Acute Improvement in Global Myocardial Work Efficiency (GWE) Compared to the Absence of This Activation Pattern, in Patients in Need of Device Implantation for Cardiac Resynchronization Therapy in Whom LBBp is Chosen Compared to the Classic Biventricular Pacing Method

Sponsor

University Hospital of Patras

Enrollment

100 participants

Start Date

May 23, 2024

Study Type

INTERVENTIONAL

Conditions

Heart Failure With Reduced Ejection Fraction (HFrEF)

Summary

The present study is a multicenter interventional non randomised study in patients requiring an implantable device for cardiac resynchronization therapy. Its primary objective is to investigate whether the presence of a specific echocardiographic contraction pattern before implantation is associated with increased rates of acute improvement in myocardial function (as measured by an ultrasound) and to compare the improvement in two groups of patients based on the type of pacing (biventricular or left-sided pacing)

Eligibility

Min Age: 18 YearsMax Age: 90 Years

Plain Language Summary

Simplified for easier understanding

This study is looking at whether a specific pattern of heart wall movement seen on a type of echocardiogram (heart ultrasound using 2D strain technology) can predict how well different pacemaker approaches — specifically left bundle branch pacing (LBBp) versus traditional biventricular pacing — will improve heart function in patients with heart failure and a specific electrical problem called left bundle branch block (LBBB). **You may be eligible if...** - You are between 18 and 90 years old - You have heart failure with reduced pumping function (ejection fraction below 35%) despite optimal medications - You have a confirmed complete left bundle branch block (LBBB) on ECG (QRS wider than 130ms with specific features) - You have been recommended for cardiac resynchronization therapy (a type of pacemaker) **You may NOT be eligible if...** - You are under 18 or over 90 - You do not meet the criteria for cardiac resynchronization therapy Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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