Characteristics and Clinical Significance of Gut Microbiota in Patients With Monoclonal Gammopathy

This study is looking at the gut bacteria (microbiome) of people with a condition called monoclonal gammopathy — where the body produces an abnormal protein in the blood that can be a precursor to blood cancers like multiple myeloma. Researchers want to understand whether the gut microbiome plays a role in whether this condition progresses to cancer. **You may be eligible if...** - You are 45 or older - You are part of a screening group with no monoclonal protein detected (healthy control), OR you have been diagnosed with a monoclonal gammopathy condition - You are able to provide blood, plasma, and stool samples **You may NOT be eligible if...** - You have a history of intestinal tumours, irritable bowel syndrome, or inflammatory bowel disease - You have recently taken antibiotics or probiotics - You have conditions or use medications that could significantly affect the gut microbiome Talk to your doctor to see if this trial is right for you.