Cavo-Tricuspid Isthmus Block Durability After Pulsed Electric Field Ablation
Systematic Assessment of the Acute Cavo-Tricuspid Isthmus Block Durability After Pulsed Electric Field Ablation
Institute for Clinical and Experimental Medicine
150 participants
Sep 16, 2024
INTERVENTIONAL
Conditions
Summary
This study seeks to assess the acute durability of the CTI block when PEF energy is used. Second goal is to establish the optimal waiting time for the conduction recovery after PEF CTI ablation and to assess the utility of routine adenosine testing for dormant conduction. Moreover, this study aims to investigate the differences in acute efficacy and adverse events (hemolysis, coronary vasospasm) between the two available configurations (basket or flower) of the pentaspline Farawave catheter (Farapulse-Boston Scientific Inc, USA).
Eligibility
Inclusion Criteria3
- patients with paroxysmal AF undergoing PVI by PEF energy with documented typical atrial flutter or patients with persistent AF in whom catheter ablation of CTI is planned as a part of a complex procedure
- Age ≥ 18 years at the time of study enrollment
- Signed informed consent
Exclusion Criteria14
- \- LA diameter \> 65 mm (measured in the parasternal long-axis view)
- History of CTI ablation in the past
- History of cardiac valve surgery
- Significant valvular defect
- Age below 18 years
- Pregnancy, breastfeeding
- Any disease with a life expectancy \<1 year
- Uncorrected congenital heart disease or valvular obstruction
- Active myocarditis
- Untreated hypothyroidism or hyperthyroidism
- Recipient of any major organ transplant (e.g., lung, liver, heart)
- HIV positivity with a survival expectancy of less than five years due to HIV
- Chronic dialysis treatment
- Unwillingness to participate.
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Interventions
catheter ablation
Catheter ablation of cavotricuspid isthmus using basket configuration of the Farapulse catheter
Locations(1)
View Full Details on ClinicalTrials.gov
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NCT06691074