PeRfusiOn Post tHrombEcTomy (PROPHET)
PeRfusiOn Post tHrombEcTomy (PROPHET) A Prospective Observational Cohort Study
Insel Gruppe AG, University Hospital Bern
279 participants
Nov 1, 2024
OBSERVATIONAL
Conditions
Summary
Endovascular mechanical thrombectomy is the standard of care for treating patients with a large-vessel occlusion acute ischemic stroke. However, in more than half of these patients, remaining distal vessel occlusions limit the benefit of this therapy. Currently the detection of residual vessel occlusions and the decision for further treatment by the operator is based on the 2D digital subtraction angiography (DSA) images. However, this technique has several limitations. Recently, a new imaging technique, with the possibility to acquire 3D time-resolved perfusion images directly in the operating room was introduced (the flat-panel detector computed tomography perfusion imaging, FDCTP). It can overcome the spatial limitations of 2D DSA, but the details on clinical validation and utility of FDCTP are currently lacking.
Eligibility
Inclusion Criteria3
- Informed consent as documented by a signature
- The patients received mechanical thrombectomy or there was the intention to perform endovascular treatment, but only diagnostic angiography was performed.
- Patients received FDCTP as clinically indicated by the treating physician.
Exclusion Criteria2
- Inability to give consent due to insufficient knowledge of the project language
- Inability to follow the clinically indicated visit at 90 days after the index stroke (e.g. patients living abroad).
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Locations(2)
View Full Details on ClinicalTrials.gov
For the most up-to-date information, visit the official listing.
NCT06691230