HIFU Versus Myomectomy for the Treatment of Symptomatic Uterine Fibroids

This study is comparing two treatments for uterine fibroids — non-cancerous growths in the uterus that can cause heavy bleeding and pelvic pain. It compares high-intensity focused ultrasound (HIFU), a non-surgical procedure that uses sound waves to shrink fibroids, with the standard surgical removal (myomectomy). **You may be eligible if...** - You are between 18 and 50 years old - You are pre- or peri-menopausal with normal hormone levels - You have a uterine fibroid between 3 and 10 cm causing symptoms like heavy periods, pressure, or pelvic pain - Your uterus is not enlarged beyond 18 weeks of pregnancy size - Your BMI is below 33 or your abdominal wall is less than 5 cm thick **You may NOT be eligible if...** - You have endometriosis, ovarian cysts, or other pelvic conditions - You are severely obese or cannot lie face-down for more than 2 hours - You have large, rapid-growing, or unusually positioned fibroids - You are pregnant, breastfeeding, or menopausal - You have a blood clotting disorder or history of blood clots or stroke - You have had previous pelvic radiation therapy - You cannot have an MRI scan Talk to your doctor to see if this trial is right for you.