RecruitingEarly Phase 1NCT06693960
Evaluating the Pharmacokinetics of Oregano and Potential Oregano-drug Interactions Using a Drug Cocktail Approach
Sponsor
Washington State University
Enrollment
16 participants
Start Date
Sep 26, 2024
Study Type
INTERVENTIONAL
Conditions
Summary
The purpose of this clinical trial is to determine how the supplement oregano affects how the body metabolizes pharmaceutical drugs.
Eligibility
Min Age: 18 YearsMax Age: 64 Years
Inclusion Criteria9
- Between 18-64 years old and healthy
- Not taking any medications (prescription and non-prescription) or dietary/herbal supplements that can interfere with study drug pharmacokinetics
- Willing to abstain from consuming dietary/herbal supplements and citrus juices for several weeks
- Willing to abstain from cannabis/marijuana, hemp, and THC- and CBD-containing products for several weeks
- Willing to abstain from consuming caffeinated beverages or other caffeine-containing products the evening before and the morning of the first day of each study arm
- Willing to abstain from consuming any alcoholic beverages for at least 1 day prior to any study day and during the study day
- Willing to use a secondary method of birth control that does not include the introduction or discontinuance of hormonal-based birth control (such as abstinence, copper IUD, or condoms). Specifically, regardless of the use hormonal-based birth control, a non-hormonal method should be used for the duration of the study and for three weeks following cessation of participation.
- Willing to abstain from consuming oregano (as a food additive or otherwise) for the duration of the study
- Geographically located within a 40-mile radius of Spokane and have the time to participate
Exclusion Criteria10
- Under 18 or over 64 years old
- Taking medications or dietary/herbal supplements that can interfere with study drug pharmacokinetics
- Have a major illness
- Taking medication/supplements for a mineral deficiency
- History of intolerance or allergy to oregano or any of the cocktail drugs (caffeine, dextromethorphan, losartan, midazolam, and omeprazole)
- Use of cannabis/marijuana, hemp, and CBD- and/or THC-containing products within the last month
- Currently using drugs or illicit substances for recreational purposes
- Pregnant or nursing
- Geographically located outside the 40-mile radius of Spokane and do not have the time to participate
- Cannot read and speak English
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Interventions
DIETARY_SUPPLEMENTOregano
Oil of oregano administered as a softgel (180 mg).
DRUGDrug cocktail
Oral drug cocktail consisting of caffeine (100 mg), dextromethorphan (30 mg), losartan (25 mg), midazolam syrup (2 mg), and omeprazole (20 mg).
Locations(1)
View Full Details on ClinicalTrials.gov
For the most up-to-date information, visit the official listing.
NCT06693960