Monocytes in Subjects With Type 1 Diabetes and Chronic Kidney Disease

This study is investigating how a type of immune cell called a monocyte behaves differently in people with type 1 diabetes who also have early kidney disease (chronic kidney disease, or CKD), compared to those with type 1 diabetes and healthy kidneys. The research may help explain why some diabetic patients develop kidney damage. **You may be eligible if...** - You are between 18 and 65 years old - You have been diagnosed with type 1 diabetes - You use an insulin pump or injections and wear a continuous glucose monitor (CGM) - For the kidney disease group: you have mild to moderate CKD (eGFR 60–90) with early protein leakage in urine (UACR 30–500 mg/g) - For the control group: your kidneys function normally with no protein in the urine **You may NOT be eligible if...** - Your hemoglobin is below 9 - You have taken GLP-1, DPP4 inhibitors, or SGLT-2 inhibitors in the past 30 days - You are pregnant or planning to become pregnant - You are taking steroids - You have been diagnosed with cancer, an autoimmune condition, or are immunosuppressed - You have heavy alcohol or recreational drug use Talk to your doctor to see if this trial is right for you.