Physiological Effects of Lung Impedance Tomography-Guided and Plat Pressure-Guided Phigh During APRV in Patients With ARDS
Physiological Effects of Lung Impedance Tomography-guided and Plat Pressure-guided Phigh During Airway Pressure Release Ventilation in Patients With Acute Respiratory Distress Syndrome
XiaoJing Zou,MD
26 participants
Jan 1, 2025
INTERVENTIONAL
Conditions
Summary
This study aims to investigate the effects of EIT-guided and Pplat-guided Phigh settings on regional ventilation and perfusion in ARDS patients during APRV, while also examining the impact of different Phigh settings on gas exchange, respiratory mechanics, and hemodynamics.
Eligibility
Inclusion Criteria2
- Diagnosed with ARDS according to the 2023 global new definition of ARDS.
- Age ≥ 18 years.
Exclusion Criteria5
- Severe chronic obstructive pulmonary disease, severe asthma, pulmonary bullae, pneumothorax, subcutaneous emphysema, mediastinal emphysema, etc. · Contraindications for EIT, such as chest wound dressing, pacemaker implantation, defibrillator use, etc.
- Pulmonary interstitial disease.
- Uncorrected shock of various types.
- Intracranial hypertension.
- Pregnant and postpartum women.
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Interventions
The Phigh level selected for the patients in the Intervention group was the intercept point of cumulated collapse and overdistension percentage curves, providing the best compromise between collapsed and overdistended lung.
Locations(1)
View Full Details on ClinicalTrials.gov
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NCT06696638