Alpha Radiation Emitters Device (DaRT) With Chemotherapy for the Treatment of Locally Advanced and Metastatic Pancreatic Cancer

This study is testing a device that delivers targeted radiation from inside a tumor (called Alpha DaRT) combined with standard chemotherapy for people with advanced pancreatic cancer that cannot be surgically removed. **You may be eligible if...** - You have been newly diagnosed with locally advanced, inoperable pancreatic cancer, OR newly diagnosed metastatic pancreatic cancer confirmed by biopsy - You will receive up to 4 cycles of standard chemotherapy (mFOLFIRINOX) before the device is inserted - Your tumor is technically accessible for the device implant - Your tumor has a measurable lesion no larger than 5 cm **You may NOT be eligible if...** - You have previously received chemotherapy or radiation for this cancer - Your tumor is not accessible for the device procedure - You have significant organ dysfunction that would prevent safe treatment Talk to your doctor to see if this trial is right for you.