RecruitingPhase 4NCT06699810

Modeling Ketosis-Prone Diabetes Remission Via Diverse Mechanisms of Glucotoxicity


Sponsor

Emory University

Enrollment

12 participants

Start Date

Jan 23, 2025

Study Type

INTERVENTIONAL

Conditions

Summary

The goal of this study is to quantify day-to-day changes in blood glucose during treatment towards remission in ketosis-prone diabetes (KPDM) and describe them using a mathematical model of KPDM pathogenesis and remission.


Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This study is investigating a type of diabetes called ketosis-prone diabetes — which can sometimes go into remission — specifically in African American adults who have experienced diabetic ketoacidosis (DKA), a serious diabetes crisis, to better understand why and how remission happens. **You may be eligible if...** - You are of African American ancestry - You have a BMI of 28 kg/m² or above - You have been diagnosed with diabetic ketoacidosis (DKA): very high blood sugar, acid build-up in the blood, and elevated ketones **You may NOT be eligible if...** - You have serious heart disease, heart failure, or chronic circulation problems - You have chronic kidney or liver disease - You have an active infection - You have an uncontrolled hormonal disorder such as untreated thyroid disease or Cushing's syndrome Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DEVICEContinuous Glucose Monitoring

After insulin discontinuation participants continue wearing their CGMs, for a total of 3 months.

DRUGInsulin

Participants will receive standard-of-care insulin treatment. Insulin dosing will be adjusted based on CGM glucose readings.


Locations(2)

Grady Health System

Atlanta, Georgia, United States

Emory University Hospital Midtown

Atlanta, Georgia, United States

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NCT06699810


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