Multi-omics Study of Early-stage Lung Cancer With Distinct Phenotypes
Comprehensive Multi-Omics Analysis of Early-Stage Lung Cancer Exhibiting Distinct Phenotypes
Central South University
300 participants
Aug 29, 2024
OBSERVATIONAL
Conditions
Summary
The goal of this observational study is to investigate the multi-omics characterization early-stage lung cancer exhibiting distinct phenotypes including lung cancer associated with cystic airspaces, multiple primary lung cancers, and so on. The main questions it aims to answer are: * What are the differences in pathogenesis of non-small cell lung cancer with different phenotypes explored by multi-omics? * Whether differential genes lead to potential prognostic models and therapeutic targets? Participants will be followed up after surgery to answer prognosis: whether they have recurred, and the time to recurrence.
Eligibility
Inclusion Criteria11
- Cohort 1: Multi-omics study in early-stage synchronous multiple primary lung cancer
- Male or female patients:18-75 years old;
- ECOG score:0-1;
- Histopathologically confirmed TNM stage I-II NSCLC;
- Considered multiple or solitary primary lung cancer by clinical criteria (Martini-Melamed criteria and ACCP criteria);
- Good compliance, family members agree to cooperate to receive survival follow-up;
- Understand and voluntarily sign the informed consent.
- Male or female patients:18-75 years old;
- ECOG score:0-1;
- Histopathologically confirmed TNM stage I-II NSCLC;
- CT findings show solitary or multiple nodules with cystic airspaces.
Exclusion Criteria7
- A history of previous or co-existing malignant tumors;
- Systemic anti-tumor therapies, including chemotherapy, radiotherapy, or targeted therapies (such as monoclonal antibodies, small-molecule tyrosine kinase inhibitors, among others), were administered prior to enrollment;
- Refusal to participate in the study.
- Cohort 2: Multi-omics study of lung cancer associated with cystic airspaces
- A history of previous or co-existing malignant tumors;
- Systemic anti-tumor therapies, including chemotherapy, radiotherapy, or targeted therapies (such as monoclonal antibodies, small-molecule tyrosine kinase inhibitors, among others), were administered prior to enrollment;
- Refusal to participate in the study.
Locations(1)
View Full Details on ClinicalTrials.gov
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NCT06699979