Multi-omics Study of Early-stage Lung Cancer With Distinct Phenotypes

This study is collecting biological samples (such as tissue) from people with early-stage non-small cell lung cancer (NSCLC) to better understand different types of tumors — including cases where multiple lung cancers appear at once, and cases where lung cancer grows near air-filled cysts in the lung. **You may be eligible if...** - You are between 18 and 75 years old - You have been confirmed to have early-stage (Stage I or II) non-small cell lung cancer - You are in generally good physical condition (able to carry out normal daily activities) - You have either multiple lung cancers appearing at the same time, or a lung cancer associated with cyst-like airspaces on a CT scan **You may NOT be eligible if...** - You have a history of another cancer - You have already received chemotherapy, radiation, or targeted cancer treatment before joining the study - You do not wish to participate Talk to your doctor to see if this trial is right for you.