A Phase 0 Multicenter Study of the Pharmacodynamic Effects of Intratumoral Microdose Administration of PBA-0111 in Patients With Solid Tumors

This early-stage study is testing a new drug (PBA-0111) by injecting tiny amounts directly into a tumor before it is surgically removed, to see how the drug affects cancer cells. It is studying people with head and neck cancer, certain soft tissue sarcomas, or triple-negative breast cancer who are already scheduled for surgery. **You may be eligible if...** - You are 18 or older - You have been diagnosed with head and neck squamous cell carcinoma (HNSCC), certain types of soft tissue sarcoma, or triple-negative breast cancer - You are scheduled to have your tumor surgically removed - Your tumor is accessible for a direct injection **You may NOT be eligible if...** - Your specific cancer type is not one of those listed in the study (e.g., not all soft tissue sarcomas qualify) - You are not able or willing to give written consent Talk to your doctor to see if this trial is right for you.