RecruitingNot ApplicableNCT06702566

The Effect of Serum Ferritin in irAE

The Significance of Serum Ferritin in the Diagnosis, Differential Diagnosis, and Prognosis of Immune-related Adverse Event (irAE)


Sponsor

Tianjin Medical University Cancer Institute and Hospital

Enrollment

1,500 participants

Start Date

Jul 4, 2024

Study Type

INTERVENTIONAL

Conditions

Summary

This is a prospective clinical study to clarify serum ferritin as a biomarker for the diagnosis, differential diagnosis and prognosis of immune-related adverse event(irAE).


Eligibility

Min Age: 18 YearsMax Age: 75 Years

Plain Language Summary

Simplified for easier understanding

This study is investigating whether a patient's serum ferritin (an iron-related protein) level can predict serious side effects (immune-related adverse events) in people with cancer who are receiving immunotherapy, targeted therapy, or chemotherapy. **You may be eligible if...** - You are between 18 and 75 years old with a confirmed diagnosis of a solid tumor or acute leukemia - You are being treated with immunotherapy, targeted therapy, or chemotherapy - Your general health is good to moderate (ECOG 0–2) - Your blood counts, liver, and kidney function meet the required thresholds **You may NOT be eligible if...** - You do not meet the required blood count, liver function, or kidney function criteria - You have not signed informed consent - Your blood oxygen level or lung function is below acceptable limits Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DRUGPD-1 and PD-L1 inhibitor

PD-1 inhibitor includes pembrolizumab,Nivolumab,Sintilimab,tislelizumab,Triplimab,Camrelizumab, Serplulimab. PD-L1 inhibitor includes durvalumab,Atezolizumab,Adebrelimab,Envafolimab.

DRUGTargeted drugs

Targeted drugs includes EGFR-TKIs,ALK-TKIs,Multitargeted Tyrosine Kinase Inhibitors, VEGF antibody, EGFR antibody, antibody-drug conjugates drugs

DRUGchemotherapy drugs

Chemotherapy drugs are determined based on the investigator's decision.


Locations(1)

Tianjin Medical University Cancer Institute and Hospital

Tianjin, Tianjin Municipality, China

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NCT06702566


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