Anticholinergics for Cervical Edema in Labor
Anticholinergics for Cervical Edema in Labor (ACCEL)
The University of Texas Health Science Center, Houston
200 participants
Mar 25, 2025
INTERVENTIONAL
Conditions
Summary
The purpose of this study is to is to determine the clinical effectiveness of a single dose of intravenous (IV) medication for the prevention of labor arrest and cesarean delivery in primiparous women undergoing trial of labor.
Eligibility
Inclusion Criteria6
- Primiparous
- Viable single intrauterine pregnancy
- ≥ 34 weeks of gestation
- Ruptured membranes
- Category I tracing at time of inclusion
- Active phase of labor (>=6 cm of cervix dilation)
Exclusion Criteria2
- Category II or III tracing
- Allergy to the study medication (IV Diphenhydramine)
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Interventions
Diphenhydramine 50mg IV will be administered within 1 hour of the cervical exam which diagnosed prolonged active phase of labor
Participants will receive cervical exams every 2 hours in active labor, placement of intrauterine pressure catheter, up titration of Pitocin if contractions are inadequate, maternal repositioning, and use of adjunct devices such as a peanut ball.
Locations(1)
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NCT06702670