RecruitingPhase 2Phase 3NCT06702670

Anticholinergics for Cervical Edema in Labor

Anticholinergics for Cervical Edema in Labor (ACCEL)

Sponsor

The University of Texas Health Science Center, Houston

Enrollment

200 participants

Start Date

Mar 25, 2025

Study Type

INTERVENTIONAL

Conditions

Labor Dystocia

Summary

The purpose of this study is to is to determine the clinical effectiveness of a single dose of intravenous (IV) medication for the prevention of labor arrest and cesarean delivery in primiparous women undergoing trial of labor.

Eligibility

Sex: FEMALEMin Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This clinical trial is studying a drug called Treatment with Diphenhydramine and Usual Care for people with labor dystocia. The study is currently recruiting participants at 1 location. People eligible for this study include women aged 18 Years and older.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DRUGTreatment with Diphenhydramine

Diphenhydramine 50mg IV will be administered within 1 hour of the cervical exam which diagnosed prolonged active phase of labor

COMBINATION_PRODUCTUsual Care

Participants will receive cervical exams every 2 hours in active labor, placement of intrauterine pressure catheter, up titration of Pitocin if contractions are inadequate, maternal repositioning, and use of adjunct devices such as a peanut ball.