RecruitingPhase 2NCT06705075

Evaluation of Uterine Fibroids by CEUS and SHAPE Pre and Post UAE

Evaluation of Uterine Fibroids by Contrast Enhanced Ultrasound (CEUS) and Subharmonic- Aided Pressure Estimation (SHAPE) Pre and Post-Uterine Artery Embolization (UAE)

Sponsor

Thomas Jefferson University

Enrollment

80 participants

Start Date

Jan 27, 2025

Study Type

INTERVENTIONAL

Conditions

Uterine Fibroid

Summary

This study goals are to determine the patterns of uterine fibroid vascularity pre and post UAE using CEUS resulting in an alternative to gadolinium-enhanced MRI that is less expensive, has less contra-indications and side effects, is real time, and noninvasive helping physicians to evaluate the result of UAE procedures. Also, this study will evaluate uterine fibroid pressures using SHAPE, comparing the results with normal myometrium tissue in order to determine its characteristics and tissue differences, which we believe will lead to the development of a new biomarker for the diagnosis and treatment of uterine fibroids.

Eligibility

Sex: FEMALEMin Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This study is evaluating new ultrasound imaging techniques to better assess uterine fibroids before and after a minimally invasive treatment called uterine artery embolization (UAE), which cuts off blood supply to fibroids to shrink them. **You may be eligible if...** - You are a woman aged 18 or older diagnosed with uterine fibroids and scheduled for UAE - If you could become pregnant, you have a negative pregnancy test - You are alert and able to follow study procedures **You may NOT be eligible if...** - You are pregnant or breastfeeding - You received an experimental drug within the last 30 days or will receive one within 72 hours after the procedure - You are medically unstable, seriously or terminally ill, or your health course is unpredictable Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DRUGPerfluten

Use of UCA Definity to evaluate uterine fibroids by contrast-enhanced ultrasound (CEUS) and subharmonic-aided pressure estimation (SHAPE) pre and post-uterine artery embolization (UAE).

Locations(1)

Thomas Jefferson University

Philadelphia, Pennsylvania, United States

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NCT06705075

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