Immunotherapy with Autologous Tregs in T1DM
Clinical Safety and Therapeutic Effects of Autologous Tregs in T1DM
The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School
20 participants
Apr 12, 2023
INTERVENTIONAL
Conditions
Summary
Type 1 diabetes (T1D) is an autoimmune disease characterized by a progressive immune distruction of pancreat beta cells and deterioration of endogenous insulin secretion. Regulatory T cells (Treg) are fuctionally deficient in T1D, leading to the loss of immune tolerance to the islets and the initiation of an autoimmune attack. Previouse studies have revealed the potential theraputic effects of autologous Treg transplantation in T1D. We have modified the preparation protocol for autologous Tregs. The purpose of this study is to assess the safety and effect of autologous Treg therapy in patients with T1D.
Eligibility
Plain Language Summary
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Interventions
Peripheral blood component donation is used to collect Treg cells for ex vivo expansion, with technical guidance provided by the Center for Biotechnology Drug Development at the Shanghai Institute of Materia Medica, Chinese Academy of Sciences.
Routine care is provided to all participants according to clinical guidelines for T1DM.
Locations(1)
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NCT06708780