RecruitingNCT06712108

Double Unit Cord Blood Transplant in Hematologic Malignancies.

PROspective Multicenter Observational Study of Double Unit Umbilical Cord Lood Transplantation in Korean Adult Patients With Hematologic Diseases.

Sponsor

Seoul National University Hospital

Enrollment

40 participants

Start Date

Dec 21, 2023

Study Type

OBSERVATIONAL

Conditions

Adult Double Unit Cord Blood Transplant

Summary

The efficacy and safety of non-myeloablative and myeloablative preconditioning followed by dual-unit umbilical cord blood transplantation from unrelated donors in adult patients with malignant hematologic diseases eligible for allogeneic hematopoietic stem cell transplantation are evaluated through prospective observation and analysis of actual clinical data collection

Eligibility

Min Age: 19 Years

Inclusion Criteria4

Aged 19 and older
Patients scheduled for umbilical cord blood transplantation as a primary allogeneic hematopoietic stem cell transplantation for the treatment of the following hematologic diseases:
Acute leukemia (myeloid/lymphoid/mixed lineage) / Myelodysplastic syndromes / Chronic leukemia (myeloid/lymphoid/monocytic) and myeloproliferative neoplasms / Malignant lymphomas, multiple myeloma / Other malignant hematologic malignancies / bone marrow failure diseases, including aplastic anemia
\- If all contents of the consent form are understood and consented to in writing.

Exclusion Criteria4

Patients with a history of allogeneic hematopoietic stem cell transplantation or those undergoing transplantation for the treatment of engraftment failure (secondary allogeneic hematopoietic stem cell transplantation is an exclusion criterion; however, patients eligible for registration include those undergoing their first allogeneic stem cell transplantation following an autologous stem cell transplantation).
Patients with severe, uncontrolled infections or severe cardiopulmonary dysfunction, as judged by the investigator.
Patients with an ECOG Performance Status (PS) greater than 3 or those receiving mechanical ventilation in the intensive care unit.
Patients who do not consent to participate in the study or those deemed unsuitable for sincere participation by the attending physician.

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Interventions

PROCEDUREtranplant

double unit cord blood transplnat

Locations(6)

Jeonbuk National University Hopital

Jeonju, Jeonlabuk-do, South Korea

Keimyung Unversity Dongsan Hospital

Daegu, South Korea

Dong-A University Hospital

Pusan, South Korea

Pusan National University Hospital

Pusan, South Korea

Seoul National University Bundang Hospital

Seongnam, South Korea

Seoul National University Hospital

Seoul, South Korea

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NCT06712108