Integrated Molecular and Clinical Profiling of Transformed Splenic Marginal Zone Lymphoma

This study collects molecular and clinical information from patients with a rare form of lymphoma called transformed splenic marginal zone lymphoma (SMZL) to better understand how it develops and behaves over time. **You may be eligible if...** - You are 18 or older - You have been diagnosed with histologically transformed splenic marginal zone lymphoma — either at initial diagnosis or after a period with the lower-grade SMZL - Tumor tissue samples (from the spleen, lymph nodes, blood, or bone marrow) collected at the time of transformation are available - Your medical records and follow-up data are available **You may NOT be eligible if...** - There are no specific exclusion criteria for this observational study Talk to your doctor to see if this trial is right for you.