ClinicalTrialsFinder
RecruitingNCT06712628

A Comparison Study of Persistence of UPadacitinib vs. TNF-inhibitoRs In a German Real-world SettING

Comparison of Persistence of UPadacitinib vs. TNF-inhibitoRs In a German Real-world SettING

Sponsor

AbbVie

Enrollment

678 participants

Start Date

Nov 7, 2024

Study Type

OBSERVATIONAL

Conditions

Moderate to Severe Rheumatoid Arthritis

Summary

This study will compare the retention rates for UPA vs. TNFi treatment in adult participants with moderate to severe active RA per local label and according to local standard of care This is a mono-country, prospective, multi-center observational study in patients with moderate to severe active RA receiving UPA or TNFi therapy. Around 678 participants will be enrolled in approximately 80 sites in Germany. Study recruitment will last approximately 24 months, and the study participation time will be up to 24 months, for a total study duration of approximately 48 months.

Eligibility

Min Age: 18 Years

Inclusion Criteria3

  • Current or Past participants with a confirmed diagnosis of moderate to severe active RA upon judgement of the treating physician.
  • Physician decision on participant treatment with Upadacitinib (UPA) or tumor necrosis factor inhibitor (TNFi) must have been reached prior to and independently of recruitment in the study
  • UPA or TNFi prescribed in accordance with the applicable approved label and local regulatory and reimbursement policies

Exclusion Criteria3

  • Participation in a clinical trial with an investigational drug (within a minimum of 30 days or 5 half-lives of the investigational drug \[whichever is longer\] prior to baseline)
  • Prior treatment with Upadacitinib
  • Prior treatment with the same tumor necrosis factor inhibitor as the one prescribed for this study

Locations(53)

Gemeinschaftspraxis Innere Medizin/Rheumatologie /ID# 278584

Freiburg im Breisgau, Baden-Wurttemberg, Germany

Rheumapraxis Heidelberg /ID# 276475

Heidelberg, Baden-Wurttemberg, Germany

Rheumapraxis Haas Tübingen /ID# 275536

Tübingen, Baden-Wurttemberg, Germany

Rheumapraxis Ulm Dr. med. Nadia Rinaldi /ID# 276293

Ulm, Baden-Wurttemberg, Germany

Dr. Med. Thomas Marycz /ID# 274646

Amberg, Bavaria, Germany

Rheumapraxis Am Webereck /ID# 274412

Augsburg, Bavaria, Germany

Dr. Harmuth /ID# 273401

Marktredwitz, Bavaria, Germany

Praxiszentrum Dr. Med. Klaus Krüger Dres. Günther Kellerer Und Paul Kellerer /ID# 276138

Munich, Bavaria, Germany

Klinische Forschung Im Medizinischen Versorgungalltag Gbr /ID# 274587

Planegg, Bavaria, Germany

Private Practice - Dr. Dirk Wernicke /ID# 276820

Hohen Neuendorf, Brandenburg, Germany

Praxis K. Pagel /ID# 279121

Hoppegarten, Brandenburg, Germany

Rheumahaus Studien GbR /ID# 275917

Potsdam, Brandenburg, Germany

Rheumatologisch Immunologisch /ID# 275830

Templin, Brandenburg, Germany

Rheumatism Center Mittelhessen /ID# 274641

Bad Endenbach, Hesse, Germany

Deutsches Endokrinologisches Versorgungszentrum DEVZ - MVZ GdR /ID# 274291

Frankfurt am Main, Hesse, Germany

Rheumapraxis Hannover-List /ID# 273735

Hanover, Lower Saxony, Germany

Praxis. F. Bigdeli-Wilshusen /ID# 273455

Hanover, Lower Saxony, Germany

Rheumatologie Kassel /ID# 275916

Kassel, Lower Saxony, Germany

Rheumapraxis An Der Hase /ID# 276949

Osnabrück, Lower Saxony, Germany

Fachpraxis für Rheumatologie und Osteologie /ID# 275359

Weyhe, Lower Saxony, Germany

Private Practice - Dr. Thilo Klopsch - Stargarder Strasse /ID# 276367

Neubrandenburg, Mecklenburg-Vorpommern, Germany

Rheumazentrum Ruhrgebiet /ID# 275518

Herne, North Rhine-Westphalia, Germany

St.Elisabeth Hospital Meerbusch /ID# 275030

Meerbusch, North Rhine-Westphalia, Germany

Rheumazentrum Ratingen /ID# 275707

Ratingen, North Rhine-Westphalia, Germany

Praxis Dr. med. Florian Beyer /ID# 274293

Kaiserslautern, Rhineland-Palatinate, Germany

Rheumapraxis am Schlossberg /ID# 272728

Homburg, Saarland, Germany

Dr. Murawski /ID# 272724

Neunkirchen, Saarland, Germany

Knappschaftsklinikum Saar /ID# 279852

Püttlingen, Saarland, Germany

Rheumapraxis Dr. Prothmann /ID# 279851

Püttlingen, Saarland, Germany

Medizinischen Versorgungszentrums Agilomed /ID# 274887

Chemnitz, Saxony, Germany

Dr. Mueller /ID# 273081

Freiberg, Saxony, Germany

Private Practice - Dr. Frank Hamann, Dr. Andreas Teich & Dr. Konrad Boche /ID# 275358

Leipzig, Saxony, Germany

Private Practice - Dr. Ilka Schwarze /ID# 276981

Leipzig, Saxony, Germany

Private Practice - Dr. Christine Baumann /ID# 275095

Plauen, Saxony, Germany

Praxis H. Fricke-Wagner /ID# 274467

Zwickau, Saxony, Germany

Rheumapraxis Dr. Liebhaber /ID# 274888

Halle, Saxony-Anhalt, Germany

Rheumatologische Facharztpraxis /ID# 272866

Magdeburg, Saxony-Anhalt, Germany

Private Practice - Dr. Jochen Walter /ID# 280069

Rendsburg, Schleswig-Holstein, Germany

Private Practice - Dr. Thomas Kupka /ID# 273631

Altenburg, Thuringia, Germany

Rheumapraxis Weimar /ID# 272740

Weimar, Thuringia, Germany

MVZ Weserbergland /ID# 276009

Bad Pyrmont, Germany

Private Practice - Dr. Silke Zinke /ID# 276366

Berlin, Germany

MVZ Herzogin Elisabeth Hospital /ID# 272725

Braunschweig, Germany

Private Practice - Dr. Sebastian Schuh /ID# 272731

Coburg, Germany

Rheumapraxis Düren /ID# 272726

Düren, Germany

Praxis Dilltal /ID# 272727

Ehringshausen, Germany

Private Practice - Dr. Daniel Bestler /ID# 272741

Erfurt, Germany

Praxis Fiene /ID# 279410

Greifswald, Germany

Private Practice - Dr. Hauke E. Heintz /ID# 278081

Hamburg, Germany

Rheumatologische Facharztpraxis /ID# 272743

Naumburg, Germany

Praxis F. Schattenberg /ID# 280322

Waren, Germany

Cellitinnen-Krankenhaus St. Josef /ID# 275926

Wuppertal, Germany

Praxis Barmen /ID# 277514

Wuppertal, Germany

View Full Details on ClinicalTrials.gov

For the most up-to-date information, visit the official listing.

Visit

NCT06712628