RecruitingPhase 1NCT06712810

Q702 for the Treatment of Patients With Hematologic Malignancies

MC220806: Phase I Study Evaluating the Efficacy of CSF1R and TAM Receptor or Inhibition in Hematologic Malignancies With Q702, a Small Molecular Inhibitor


Sponsor

Mayo Clinic

Enrollment

46 participants

Start Date

Aug 27, 2025

Study Type

INTERVENTIONAL

Conditions

Summary

This phase I trial tests the safety, side effects, and best dose of Q702 in treating patients with hematologic malignancies. Q702 is in a class of medications called immunomodulatory agents. It works by helping the immune system kill cancer cells and by helping the bone marrow to produce normal blood cells. Giving Q702 may be safe, tolerable and/or effective in treating patients with hematologic malignancies.


Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This study tests Q702, a drug that targets specific cancer-driving genetic changes, in patients with rare blood and immune system cancers called histiocytic disorders (such as Erdheim-Chester disease, Langerhans cell histiocytosis, or histiocytic sarcoma) that do not have BRAF or MAP2K mutations. **You may be eligible if...** - You are 18 or older - You have a confirmed histiocytic disorder without BRAF or MAP2K gene mutations - Your cancer has relapsed or stopped responding after at least one prior treatment - You are not eligible for or have exhausted standard therapies **You may NOT be eligible if...** - Your cancer has activating BRAF or MAP2K mutations (other targeted therapies may be more appropriate) - You have not yet had a first line of treatment - You do not meet the health criteria set by the treating physician Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DRUGAxl/Mer/CSF1R Inhibitor Q702

Given PO

PROCEDUREBiospecimen Collection

Undergo blood and urine sample collection

PROCEDUREBone Marrow Aspiration

Undergo bone marrow biopsy and aspiration

PROCEDUREBone Marrow Biopsy

Undergo bone marrow biopsy and aspiration

PROCEDUREComputed Tomography

Undergo CT scan

PROCEDUREMagnetic Resonance Imaging

Undergo MRI

PROCEDUREPositron Emission Tomography

Undergo PET scan

OTHERSurvey Administration

Ancillary study


Locations(2)

Mayo Clinic in Arizona

Scottsdale, Arizona, United States

Mayo Clinic in Rochester

Rochester, Minnesota, United States

View Full Details on ClinicalTrials.gov

For the most up-to-date information, visit the official listing.

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NCT06712810


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