RecruitingNot ApplicableNCT06713733
Comparison of Clinical Efficacy of Submucosal Dexamethasone and Oral Trypsin-chymotrypsin for Reduction of Postoperative Sequelae After Lower Third Molar Surgery
Sponsor
B.P. Koirala Institute of Health Sciences
Enrollment
50 participants
Start Date
Sep 25, 2024
Study Type
INTERVENTIONAL
Conditions
Summary
Pain, edema and trismus are the most frequent postoperative sequelae to surgical removal of impacted teeth, all of are due to the local inflammatory response. Use of corticosteroids decrease tissue mediators of inflammation and reduce edema. Use of trypsin-chymotrypsin elaborates the enzymes esterase in blood plasma that inhibits inflammation by hydrolytic degradation of the inflammatory peptides.
Eligibility
Min Age: 18 Years
Inclusion Criteria4
- Clinically healthy patients (ASA I) patient free of any systemic diseases that could interfere with wound healing or surgical operation.
- Free of any recent anti-inflammatory drug intake or being under long term treatment with medicaments that will obscure the assessment of the inflammatory response as NSAIDs, steroids, or antihistamines
- Free from allergy to the drugs used in the study
- Patients requiring surgical removal of the mandibular impacted third molar
Exclusion Criteria5
- Patients who are ASA II to ASA VI.
- Patients already on corticosteroids through any route.
- Patients with known allergy to any drugs.
- Pregnant and lactating females
- Patient not consenting to participate in the study
Interested in this trial?
Get notified about updates and connect with the research team.
Interventions
DRUGDexamethasone
local infiltration
DRUGChymotrypsin
orally given
Locations(1)
View Full Details on ClinicalTrials.gov
For the most up-to-date information, visit the official listing.
NCT06713733