RecruitingNCT06714318

SMARTER: Using Blood Samples to iMprove FIT-bAsed coloRecTal cancEr scReening

Sponsor

Vejle Hospital

Enrollment

1,000 participants

Start Date

Dec 2, 2024

Study Type

OBSERVATIONAL

Conditions

Colorectal, Cancer

Summary

The project aims to investigate whether colorectal cancer screening can be improved using blood tests, thereby reducing the number of unnecessary colonoscopies. The Danish colorectal cancer screening program was implemented in 2014, and currently, all individuals aged 50-74 are invited every two years to participate. Those who test positive for hidden blood in their stool are referred for a colonoscopy. More than a third of the approximately 25,000 colonoscopies performed annually in the screening program can be classified as unnecessary, as they reveal a normal colon. This results in avoidable and unpleasant procedures for individuals and strains healthcare resources. The project seeks to reduce the number of these unnecessary colonoscopies by investigating whether blood biomarkers can identify individuals at very low risk of colorectal cancer after a positive stool test for hidden blood. By utilizing blood tests, screening could become more personalized, precise, and resource-efficient for the healthcare system.

Eligibility

Min Age: 50 YearsMax Age: 74 Years

Plain Language Summary

Simplified for easier understanding

This study (SMARTER) is looking at whether adding a simple blood test to the existing bowel cancer screening program — which uses a stool sample test called a FIT test — can help detect colorectal (bowel) cancer earlier and more accurately. Researchers want to see if combining these two approaches catches more cancers that might be missed by the stool test alone. **You may be eligible if...** - You are already enrolled in a colorectal cancer (bowel cancer) screening program - You completed a follow-up colonoscopy as part of your screening **You may NOT be eligible if...** - You did not complete a colonoscopy as part of your screening follow-up (the only exception is if a bowel tumor was physically blocking the colonoscope from passing) Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Locations(2)

Hospital Sønderjylland

Aabenraa, Denmark

Vejle Hospital

Vejle, Denmark

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NCT06714318

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